Investors

Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 28 4.09 37.66 1,602,502
Mutual Fund 4 0.10 0.94 40,149
Insider 8 0.17 2.67 113,577

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 10 2.54 25.40 1,080,918
Sellers 16 -0.21 2.33 -99,305
Net -- 2.33 23.07 981,613

Concentration

Value ($MM) % O/S Shares
Total Inst. 4.09 37.66 1,602,502
Top 10 Inst. 3.82 34.40 1,463,757
Top 20 Inst. 4.01 37.00 1,574,645
Top 50 Inst. 4.09 37.66 1,602,502

Style

Holders Value ($MM) % Inst Shares Shares
Growth 2 0.03 0.37 15,718
Core Growth 2 0.03 0.37 15,718
Index 2 0.05 0.63 26,775
Other 6 1.56 16.02 681,533
Broker Dealer 3 0.25 3.07 130,527
Hedge Fund 3 1.31 12.95 551,006
Value 2 0.03 0.37 15,709
Core Value 1 0.01 0.11 4,690
Deep Value 1 0.02 0.26 11,019

Location: Global Region

Holders % O/S Shares Share Change
North America 15 27.12 1,154,080 1,055,879
Europe 2 0.23 9,582 4,782

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Lincoln Park Capital 393,552 9.25 393,552 4/9/18
Anson Funds Management LP. 377,652 8.87 377,652 4/9/18
Intracoastal Capital, L.L.C. 186,400 4.38 186,400 4/18/18
Sabby Management, LLC 168,462 3.96 168,462 6/30/18
SG Americas Securities, L.L.C. 118,387 2.78 118,387 6/30/18
Eliseev (Alexey V) 95,031 2.23 13,250 9/7/17
OPKO Health, Inc. 44,635 1.05 -1 12/31/17
Cauwenbergh (Geert) 34,978 0.82 21,000 8/1/18
The Vanguard Group, Inc. 25,660 0.60 7,363 6/30/18
DRW Securities, LLC 19,000 0.45 -- 6/30/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Extended Market Index Fund 25,660 0.60 7,363 6/30/18
Fidelity Extended Market Index Fund 9,194 0.22 6,531 6/30/18
Perinvest (Lux) Sicav Global Healthcare Equity 4,892 0.11 92 12/31/16
iShares Core S&P Total U.S. Stock Market ETF 403 0.01 -- 7/31/18

* Insider values reflect direct beneficial ownership.

Copyright Thomson Reuters Corporation