Investors

Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 24 2.56 19.08 452,118
Mutual Fund 4 0.06 0.41 9,756
Insider 4 6.38 46.99 1,113,568

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 8 0.06 0.46 10,838
Sellers 11 -0.09 0.71 -16,903
Net -- -0.03 0.25 -6,065

Concentration

Value ($MM) % O/S Shares
Total Inst. 2.56 19.08 452,118
Top 10 Inst. 2.49 18.59 440,578
Top 20 Inst. 2.56 19.08 452,031
Top 50 Inst. 2.56 19.08 452,118

Style

Holders Value ($MM) % Inst Shares Shares
Index 4 0.04 0.28 6,747
Other 7 0.11 0.76 17,903
Broker Dealer 3 0.03 0.25 5,838
Hedge Fund 4 0.07 0.51 12,065
Value 1 -- -- 1
Core Value 1 -- -- 1

Location: Global Region

Holders % O/S Shares Share Change
North America 14 0.98 23,313 8,836
Europe 1 0.21 4,892 92

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Barberich (Timothy Joseph) 140,845 5.94 40,712 8/10/17
Wolfson (Alexey) 127,398 5.38 33,249 8/10/17
Eliseev (Alexey V) 95,031 4.01 -20,000 9/7/17
OPKO Health, Inc. 44,636 1.88 22,222 12/21/16
Cauwenbergh (Geert) 14,708 0.62 1,000 10/2/17
Perinvest (UK) Ltd. 4,892 0.21 92 12/31/16
Two Sigma Investments, LP 4,221 0.18 -1,705 12/31/17
Susquehanna Financial Group, LLLP 3,232 0.14 3,232 12/31/17
Citadel LLC 2,951 0.12 1,411 12/31/17
Geode Capital Management, L.L.C. 2,664 0.11 -- 12/31/17

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Perinvest (Lux) Sicav Global Healthcare Equity 4,892 0.21 92 12/31/16
Fidelity Extended Market Index Fund 2,664 0.11 -- 12/31/17
Vanguard Extended Market Index Fund 1,797 0.08 -- 1/31/18
iShares Core S&P Total U.S. Stock Market ETF 403 0.02 2 1/31/18

* Insider values reflect direct beneficial ownership.

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