Investors

Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 29 6.24 45.24 1,925,024
Mutual Fund 4 0.09 0.62 26,255
Insider 2 0.70 3.43 146,083

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 17 3.38 30.57 1,300,842
Sellers 12 -0.12 0.67 -28,468
Net -- 3.26 29.90 1,272,374

Concentration

Value ($MM) % O/S Shares
Total Inst. 6.24 45.24 1,925,024
Top 10 Inst. 5.80 42.43 1,805,637
Top 20 Inst. 6.23 45.19 1,923,217
Top 50 Inst. 6.24 45.24 1,925,024

Style

Holders Value ($MM) % Inst Shares Shares
Growth 1 0.03 0.23 10,000
Core Growth 1 0.03 0.23 10,000
Index 2 0.06 0.46 19,412
Other 6 2.07 18.84 801,772
Broker Dealer 3 0.13 0.98 41,576
Hedge Fund 3 1.94 17.86 760,196
Value 1 0.06 0.47 20,019
Deep Value 1 0.06 0.47 20,019

Location: Global Region

Holders % O/S Shares Share Change
North America 18 30.78 1,309,820 1,300,749
Europe 1 0.11 4,892 92

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Lincoln Park Capital 393,552 9.25 393,552 4/9/18
Sabby Management, LLC 377,652 8.87 377,652 4/9/18
Anson Funds Management LP. 377,652 8.87 377,652 4/9/18
Intracoastal Capital, L.L.C. 186,400 4.38 186,400 4/18/18
Barberich (Timothy Joseph) 140,845 3.31 40,712 8/10/17
Wolfson (Alexey) 127,398 2.99 33,249 8/10/17
Eliseev (Alexey V) 95,031 2.23 -20,000 9/7/17
OPKO Health, Inc. 44,635 1.05 -1 12/31/17
MYDA Advisors LLC 41,648 0.98 41,648 3/31/18
Virtu Americas LLC 20,824 0.49 18,283 3/31/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Extended Market Index Fund 18,297 0.43 -- 4/30/18
Perinvest (Lux) Sicav Global Healthcare Equity 4,892 0.11 92 12/31/16
Fidelity Extended Market Index Fund 2,663 0.06 -1 3/31/18
iShares Core S&P Total U.S. Stock Market ETF 403 0.01 -- 4/30/18

* Insider values reflect direct beneficial ownership.

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