Investor Relations

Institutional Ownership

Institutional Ownership

Shareholders

Shareholder Holders Value ($MM) % O/S Shares
Institution 26 3.93 13.45 2,443,250
Mutual Fund 4 0.08 0.24 44,178
Insider 8 0.29 1.23 222,913

Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 9 2.38 9.12 1,655,726
Sellers 11 -0.37 1.52 -275,492
Net -- 2.01 7.60 1,380,234

Concentration

Value ($MM) % O/S Shares
Total Inst. 3.93 13.45 2,443,250
Top 10 Inst. 3.77 12.83 2,330,272
Top 20 Inst. 3.92 13.40 2,434,314
Top 50 Inst. 3.93 13.45 2,443,250

Style

Holders Value ($MM) % Inst Shares Shares
Growth 2 0.02 0.09 15,718
Core Growth 2 0.02 0.09 15,718
Index 2 0.04 0.17 30,975
Other 5 1.16 3.06 556,091
Broker Dealer 2 0.19 0.90 164,278
Hedge Fund 3 0.97 2.16 391,813
Value 1 0.01 0.06 10,790
Core Value 1 0.01 0.06 10,790

Location: Global Region

Holders % O/S Shares Share Change
North America 14 10.02 1,819,773 1,647,451
Europe 1 0.06 10,790 6,100

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Heights Capital Management, Inc. 814,237 4.48 814,237 10/1/18
Lincoln Park Capital 393,552 2.17 393,552 4/9/18
Anson Funds Management LP. 377,652 2.08 377,652 4/9/18
Intracoastal Capital, L.L.C. 186,400 1.03 186,400 4/18/18
SG Americas Securities, L.L.C. 163,730 0.90 45,343 9/30/18
Cauwenbergh (Geert) 163,012 0.90 54,447 11/9/18
Barberich (Timothy Joseph) 140,844 0.78 -1 3/15/18
OPKO Health, Inc. 44,635 0.25 -1 12/31/17
The Vanguard Group, Inc. 29,860 0.16 4,200 9/30/18
Dispersyn (Gerrit) 16,350 0.09 16,000 8/1/18

Top Holders: Mutual Funds

Fund Shares Held % O/S Share Change Filing Date
Vanguard Extended Market Index Fund 29,860 0.16 4,200 9/30/18
Fidelity Extended Market Index Fund 9,023 0.05 -171 9/30/18
Perinvest (Lux) Sicav Global Healthcare Equity 4,892 0.03 92 12/31/16
iShares Core S&P Total U.S. Stock Market ETF 403 -- -- 10/31/18

* Insider values reflect direct beneficial ownership.

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