19th Annual TIDES: Oligonucleotide and Peptides Therapeutics Conference

Apr 30 - May 3, 2017

Date and Time: Tuesday, May 2, 2017 9:30 am PDT
Title: Reduced in vivo Tumor Growth Using CAR T-cells Treated ex vivo with PD-1 Targeting sd-rxRNA®
Track: Oligonucleotide Discovery, Preclinical and Clinical

Abstract: Silencing of immunosuppressive genes, such as PD-1, by ex vivo treatment with a self-delivering RNAi (sd-rxRNA) may improve the efficacy of CAR-T cells for the treatment of solid tumors. Meso-CAR-T cells (expressing antibody fragments that target mesothelin) were treated ex vivo with an anti-PD-1 sd-rxRNA. Direct tumor injection of these modified CAR-T cells in a mouse model of human ovarian cancer resulted in a statistically significant reduction of tumor growth.

Supporting Materials


Manchester Grand Hyatt
San Diego, California.